Development of new electrode material for the electrochemical detection of organic molecules of pharmaceutical interest

Abstract

In this study, the electrochemical behavior of Atorvastatin (ATOR) and Ramipril (RAM) was investigated on multi-walled carbon nanotubes (MWCNTS) modified glassy carbon electrode (GCE) as simultaneously. A simple and highly sensitive square wave voltammetry (SWV) technique was developed for the simultancous electrochemical determination of ATOR and RAM in 0.1M BRB solution (pH 3.0). The oxidation process of both analytes was found to be irreversible and exhibited mixed diffusion under adsorption-controlled process. The oxidation mechanism of drugs was proposed using the obtaincd data and discussed. The MWCNTS/GCE showed an enhancement effects on the oxidation current of ATOR and RAM with the significant peak potential differences of 0.27 V by SWV technique. At the optimum conditions, the proposed method exhibited linear responses in concentration ranges 10-100 uM for ATOR and RAM with the detection limits of 2.57 and 1.87 µM respectively.